BioTuring's Blog - Data analysis made easy. For biologists, especially.
Data analysis made easy. For biologists, especially.
Zooming in the intratumoral heterogeneity of liver cancer with BBrowser single cell database
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intratumoral heterogeneity - liver cancer cell composition

Introduction  Why are tumors so resilient against available cancer therapies? One answer lies in intratumoral heterogeneity.  Intratumoral heterogeneity describes the diversity in tumor cell populations. Cancer cells exhibit startling distinctions in their types, shape, metabolic activities, transcriptomic profiles, and more. The causes of intratumoral heterogeneity are both heritable (clonal expansion […]

Explore 10X Visium Spatial Transcriptomics data at ease with BioTuring Browser
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Cells don’t function independently. They belong to a complex and interconnected network. This makes gene expression profiling of individual cells not enough for understanding their activities and crosstalk in the tissue context.  Like a marriage between imaging and RNA sequencing, Spatial Transcriptomics is a revolutionized method to map gene activity […]

A tiny world inside non-small cell lung cancer revealed by single-cell omics: 35 cell types, and their marker genes
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Take a non-small cell lung tumor. What do we see? To answer this challenging question, a lot of single-cell omics experiments have been conducted, yielding significant insights into the heterogeneity of non-small cell lung cancer (NSCLC) microenvironment. While each successfully characterizes a facet of this ecosystem, until now no work […]

Immunoglobulin genes up-regulated in lung adenocarcinoma infiltrating T cells: A report from BioTuring lung cancer single cell database
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Highlights: In every biology textbook, expression of the B cell receptor (BCR) defines B cells, and the T cell receptor (TCR) defines T cells. However, in 2019, Ahmed et al. discovered a strange cell population in Type I Diabetes that coexpresses the BCR and TCR, and key lineage markers of […]

BioVinci: high-dimensional data visualization made easy for biologists
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“How to extract the biology behind this huge matrix of thousands of rows and columns?”  Large numbers of data points hold valuable biological stories yet are tricky to graph and analyze. Imagine you had the data for 1000 features and observations, your mind would be full of questions, wondering how […]

Single-cell analysis of CD8+ T cells in immune checkpoint blockade: some reproducible insights from BioTuring Database
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Cancer treatment, as challenging as it sounds, has been revolutionized by recent advances in immune checkpoint blockade (ICB) therapies, which use monoclonal antibodies (mAb) to block the suppressive immune checkpoints, helping the patient’s immune system to kill cancer cells. However, despite several clinical case studies of success, some patients still […]