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The Basics of DESeq2 – A Powerful Tool in Differential Expression Analysis for Single-cell RNA-Seq
deseq2 single cell example

Differential expression analysis is a common step in a Single-cell RNA-Seq data analysis workflow. In our previous post, we have given an overview of differential expression analysis tools in single-cell RNA-Seq. This time, we’d like to discuss a frequently used tool – DESeq2 (Love, Huber, & Anders, 2014).  According to […]

The Maze of Differential Gene Expression Analysis in Single-cell RNA-Seq
scrna seq differential expression - venice

Single-cell RNA sequencing (scRNA-seq) unfolds biological processes at individual cell resolution. One key step that makes up the power of scRNA-seq is the spotting of differentially expressed (DE) genes. However, characteristics like high heterogeneity and data sparsity (high zero counts) are the main obstacles in finding DE genes in scRNA-seq […]